LXXI.—The isonitrile of phenylhydrazine
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چکیده
منابع مشابه
NSRL for Phenylhydrazine and Phenylhydrazine Hydrochloride
The cancer potencies of phenylhydrazine and phenylhydrazine hydrochloride were estimated from dose-response data from three data sets: lung tumors among male and female mice (combined) exposed orally to phenylhydrazine hydrochloride (Clayson et al., 1966) and blood vessel tumors among male and female mice exposed orally to phenylhydrazine hydrochloride (Toth and Shimizu, 1976). Studies of pheny...
متن کاملPhenylhydrazine haematotoxicity
Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th century but with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation, peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-ind...
متن کاملTotal synthesis of (+/-)-welwitindolinone a isonitrile.
A highly stereoselective total synthesis of the alkaloid natural product welwitindolinone A isonitrile has been completed. The synthesis utilizes a chloronium ion mediated semi-pinacol rearrangement to simultaneously install the C10 quaternary center and neopentyl chlorine and a novel anionic cyclization to construct the spiro-oxindole with complete stereocontrol.
متن کاملThe Reaction of Phenylhydrazine with Microsomal Cytochrome
Phenylhydrazine interacted with oxidized and reduced cytochrome P-450 of rat liver microsomes to produce binding difference spectra typical of many nitrogenous compounds. The phenylhydrazine-induced difference spectrum observed with oxidized microsomal cytochrome P-450 was converted, in a time-dependent process, t o yield a new spectral intermediate with an absorbance maximum around 480 nm. ...
متن کاملThe oxidation of phenylhydrazine by tyrosinase.
Tyrosinase was found to catalyze the oxidation of phenylhydrazine to phenol in a reaction that did not resemble those typically performed by tyrosinase. The kinetics of this reaction was investigated by measuring the initial velocity of the formation of phenol (25 °C). The values of k cat and K M for the oxidation of phenylhydrazine were obtained as 11.0 s(-1) and 0.30 mM, respectively. The gen...
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ژورنال
عنوان ژورنال: J. Chem. Soc., Trans.
سال: 1888
ISSN: 0368-1645
DOI: 10.1039/ct8885300850